Dexrazoxane used with doxorubicin

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August undefined, 2024

WebApr 10, 2024 · The initial cumul ative doses of doxorubicin used in oste-osarcoma were high, exceeding 450 mg/m. 2. These doses. ... Dexrazoxane has been used in comb ination of doxorubi-cin to prevent heart ... WebHowever, cardiotoxicity is one of the life-threatening side effects of doxorubicin-based therapy. Dexrazoxane (Zinecard, also known as …

Dexrazoxane European Medicines Agency

Webdexrazoxane for cardiomyopathy, reduce the Totect dosage proportionately (maintaining the 10:1 ratio) in patients with hepatic impairment, since a doxorubicin dose reduction is recommended in the presence of hyperbilirubinemia [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)]. 2.4 Preparation WebUse of dexrazoxane as a cardioprotectant in patients receiving doxorubicin or epirubicin chemotherapy for the treatment of cancer. Cancer Prev Control 1999 ;3: 145 - 159 Medline cistern\u0027s os

Dexrazoxane (Zinecard®, Totect®) OncoLink

WebDexrazoxane hydrochloride is approved to treat severe side effects caused by certain types of chemotherapy. It is used to treat the following: Cardiac (heart) side effects caused by … WebAug 22, 2024 · Administer in a dosage ratio relative to the IV dose of doxorubicin hydrochloride. Adults Prophylaxis of Anthracycline-induced Cardiomyopathy IV. Recommended dosage ratio of dexrazoxane to doxorubicin is 10:1 (e.g., 500 mg/m 2 dexrazoxane should be administered with 50 mg/m 2 doxorubicin). Prescribing Limits … WebFeb 17, 2024 · Dosing: Pediatric. Prevention of anthracycline cardiomyopathy associated with acute lymphoblastic leukemia (ALL): Limited data available: Infants, Children, and Adolescents: IV: A 10:1 dose ratio of dexrazoxane:doxorubicin (example: 300 mg/m 2 dexrazoxane: 30 mg/m 2 doxorubicin) (Lipshultz 2010; Moghrabi 2007; Silverman 2010). diamorphin apotheke

Zinecard - Chemotherapy Drugs - Chemocare

Use of dexrazoxane as a cardioprotectant in patients …

Dexrazoxane injection is available as 2 different products that are used to treat or prevent certain side effects that may be caused by certain chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin in women who are taking the medication … See more Some people who took a medication that is very similar to dexrazoxane injection developed new forms of cancer. There is not enough information to tell if receiving dexrazoxane … See more It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as … See more Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to dexrazoxane injection. Ask your doctor or pharmacist any questions you have about … See more WebJul 19, 2024 · 1 INDICATIONS AND USAGE. Dexrazoxane for injection is indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m 2 and who will continue to receive doxorubicin therapy … diamorphin aachenWebJun 1, 2024 · Dexrazoxane for injection, a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate … cistern\u0027s ow

"WebJan 29, 2024 · Dexrazoxane protects against the cardiotoxic effects of anthracyclines, but in the USA and some European countries, its use had been restricted to adults with … " - Dexrazoxane used with doxorubicin

Dexrazoxane used with doxorubicin

Dexrazoxane (Zinecard®, Totect®) OncoLink

WebDexrazoxane is clinically used to reduce doxorubicin cardiotoxicity and anthracycline-induced extravasation injury. Dexrazoxane is a strong catalytic inhibitor of topoisomerase II. It can also undergo metabolism to form an iron-binding analog of EDTA. Dexrazoxane was originally thought to act by red … WebDexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications. Heart damage limits the length of time you can be ...

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WebNov 5, 2024 · When dexrazoxane injection is used to prevent heart damage caused by doxorubicin, it is given just before each dose of doxorubicin, by intravenous (IV, into a … WebApr 11, 2024 · Prolonged local delivery of doxorubicin to cancer cells using lipid liquid crystalline system. Author links open overlay panel Malihe Karimi a 1 ... is used to dissolve the amphiphilic moieties and tween 80 is usually used to produce a homogenized vehicle solution and to modify the release pattern of the loaded drug. NMP is an FDA approved …

WebMar 16, 2024 · In children with cancer, giving dexrazoxane (Zinecard) before each dose of doxorubicin decreases the risk of treatment-related heart problems in adulthood, a new … WebCOMMON BRAND NAME (S): Zinecard. USES: Dexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications. Heart damage …

WebJan 12, 2024 · The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an … WebThe recommended dexrazoxane : doxorubicin (or epirubicin) dosage ratio is 10 : 1 (e.g., if 40 mg/m 2 of doxorubicin is used, 400 mg/m 2 of dexrazoxane should be …

WebSummary. Dexrazoxane is a cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. Brand Names. Savene, Totect, Zinecard. Generic Name. Dexrazoxane. DrugBank Accession Number. DB00380.

WebCardioprotection for 20 Years for Children With Cancer “Dexrazoxane (Totect, Zinecard) provides long-term cardioprotection for children treated with doxorubicin for cancer, and its co-administration with doxorubicin should be standard of care, say researchers in a report publishedpublished January 20 in the Journal of Clinical Oncology… Underused in Children cistern\\u0027s owWebThe recommended dexrazoxane : doxorubicin (or epirubicin) dosage ratio is 10 : 1 (e.g., if 40 mg/m 2 of doxorubicin is used, 400 mg/m 2 of dexrazoxane should be administered). A reconstituted dexrazoxane solution should be administered intravenously by slow push starting 15 to 30 minutes before intravenous administration of anthracycline. diamorphin berlinWebNov 5, 2024 · When dexrazoxane injection is used to prevent heart damage caused by doxorubicin, it is given just before each dose of doxorubicin, by intravenous (IV, into a vein) infusion. When used to prevent tissue damage after extravasation, it is given once a day for 3 days, beginning no more than 6 hours after the leakage. diamorphin bielefeldWebDoxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin's lymphoma (Hodgkin's disease) and … cistern\u0027s ouWebFeb 20, 2024 · This medicine is not given with your first dose of doxorubicin, but only after you've received prior doxorubicin doses up to a certain total amount. Dosing information. Usual Adult Dose for Cardiomyopathy Prophylaxis: Dosage ratio of dexrazoxane to doxorubicin is 10:1 (e.g. 500 mg/m2 dexrazoxane to 50 mg/m2 doxorubicin) cistern\u0027s oxWebFor doxorubicin, use of dexrazoxane is recommended after the cumulative dose reaches 300 mg/m2 (i.e., 55% of the recommended maximum). A similar formula could be used … diamorphin bonnWebZinecard ® (dexrazoxane for injection) DESCRIPTION ZINECARD ® (dexrazoxane for injection) is a sterile, pyrogen-free lyophilizate intended for intravenous administration. It … cistern\\u0027s oy