Cyclosporine monoclonal assay
WebDocument: Lethally irradiated rats reconstituted with syngeneic bone marrow and treated with cyclosporine (CsA) for 40 d develop a graft-vs.-host disease-like syndrome (GVHD) after CsA therapy. We attempted to assess the development of autoreactivity in these animals. Results revealed that a majority of the animals with syngeneic GVHD develop … WebDec 1, 1990 · A monoclonal antiserum that is specific for cyclosporine is the assay of choice.l, 2, 4 The poly- clonal immunoassays detect the parent compound as well as a variety of metabolites. Thus, for a given sample, an assay that uses a polyclonal antibody will yield much higher results than one that uses a spe- cific monoclonal antibody or an …
Cyclosporine monoclonal assay
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WebMar 7, 2024 · Cyclosporine is an immunosuppressive agent used to treat organ rejection post-transplant. It also has use in certain other autoimmune diseases, treatment of organ … WebSep 1, 2000 · The TDx monoclonal antibody appears to have a lesser degree of specificity than that used in the Emit assay. Mean concentrations of cyclosporine measured by Emit and TDx were 17% and 51% higher ...
WebThe ADVIA Centaur® Cyclosporine assay is a competitive immunoassay using direct chemitumninescent technology. Cyclosporine in the patient sample competes with … WebApr 30, 2015 · Cyclosporine is a potent immunosuppressive agent that in animals prolongs survival of allogeneic transplants involving skin, kidney, liver, heart, pancreas, bone marrow, small intestine, and lung ... INDICATIONS AND USAGE
WebWe compared cyclosporine concentrations in whole blood as measured by HPLC and by RIA with a monoclonal antibody specific for cyclosporine with 3 H- or 125 I-labeled cyclosporine ligand. The 3 H-RIA kit slightly underestimated cyclosporine concentrations (>600 μg/L) in comparison with HPLC. WebThe CEDIA® Cyclosporine PLUS assay is for the in vitro quantitative determination of cyclosporine in human whole blood using automated clinical chemistry analyzers as an …
WebThe ARCHITECT Cyclosporine assay is used as an aid in the management of heart, liver and kidney transplant patients receiving cyclosporine therapy. The …
WebMar 1, 1999 · Cyclosporine (CsA) is a cyclic undecapeptide that has potent immunosuppressive activity, but its narrow therapeutic range and variable pharmacokinetics in humans make monitoring of CsA mandatory ().The generally accepted whole-blood therapeutic ranges of CsA (with specific assay) are 100–200 μg/L for renal transplant … earlston high school holidays 2022WebCyclosporine is a natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may … css pseudo class for clickWebMar 2, 2001 · Cyclosporine monoclonal whole-blood assay and AxSYM Cyclosporine II Dinapak, based on the FPIA method, were purchased from Dinabott. The Cyclo-Trac SP whole-blood cyclosporine RIA kit was from Dade Behring Co., Ltd. HPLC was carried out according to the procedure of Kovarik et al. (13) using a Phenomenex LUNA 5 µm C18, … cssps headsWebApr 1, 1998 · Cyclosporine (CsA) is a cyclic undecapeptide of fungal origin and was first introduced for the prevention of graft rejection more than a decade ago. CsA had a major impact on the result of solid organ transplantation, … cssps hackWebSteimer, W, Performance and specificity of monoclonal immunoassays for cyclosporine monitoring: How specific is specific? Clinical Chemistry 1999;45:371-381. 10. cssps evoucherWebCyclosporine Test system -Class II Special controls Clinical Toxicology Calibrator 3. Identification of the Predicate Devices Abbott TDxa/TDxFLx® Cyclosporine Monoclonal Whole Blood assay, P890025 4. Device Description The ADVIA Centaur® Cyclosporine assay is a competitive immunoassay using direct chemitumninescent technology. earlston high school timesWebFeb 1, 1991 · The monitoring of cyclosporine levels in whole blood and serum has become a routine procedure for the post-transplant management of immunosuppression. We have developed fluorescence polarization immunoassays for cyclosporine in whole blood and in serum using a monoclonal antibody. cssp sindh