Cisplatin hearing loss data

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August undefined, 2024

WebAfter the first cycle of cisplatin, in the placebo ears, 76% of patients experienced hearing loss in the clinical frequency range that met the ototoxicity criteria established by the American Speech-Language-Hearing Association. WebOct 6, 2024 · Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing loss may result from damage caused by the …

Study characterizes cisplatin-induced hearing loss in pediatric …

WebModern research on ototoxicity goes back to the 1940s, when streptomycin was introduced into clinical practice. Today, aminoglycoside antibiotics and platinum-based chemotherapy, mainly cisplatin, are the most important drugs that … WebFeb 12, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not … immigration akron ohio

Molecules Free Full-Text The Challenging Treatment of Cisplatin ...

WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease … WebSep 21, 2016 · Individually, children in this series first showed decreases in hearing after cumulative cisplatin doses ranging between 75 and 600 mg/m 2 and carboplatin doses between 800 and 3,420 mg/m 2. Patients treated for germ cell tumors (Children's Oncology Group 8882) received the highest cumulative doses of cisplatin. WebFeb 15, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not … immigration agent surrey

Long After Chemotherapy, Cisplatin and Hearing Loss Remain

Cisplatin and Hearing Loss: Until Now, an Unquantified Risk

WebJan 26, 2024 · But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant … immigration agents sunshine coastWebOct 6, 2024 · Sodium thiosulfate prevents hearing loss and is safe Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing loss may result from damage caused by the accumulation of cisplatin in the inner ear. immigration amendment act

"WebAfter the cisplatin treatment marked hearing loss were detected, with ABR thresholds increasing to 34.5 ± 16.1 dB, 40.8 ± 16.7 dB, and 43.7 ± 18.2 dB at 8, 16, and 32 kHz, respectively. NS, normal saline; dB, decibel; ABR, auditory brainstem response. 2.2. Auditory Brainstem Response (ABR) " - Cisplatin hearing loss data

Cisplatin hearing loss data

Sodium Thiosulfate Reduces Hearing Loss in Kids with Cancer

WebDec 11, 2024 · It is used for the treatment of a variety of cancers such as cervical, breast, stomach, prostate, bladder and oesophageal, to name a few. However due to its expansive toxicity profile, patients receiving cisplatin can experience high frequency hearing loss, a side effect known as ototoxicity. WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this …

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Web顺铂治疗导致的永久性听力损失率在 40% 到 80% 之间，并且与相当大的发病率和对生活质量的负面影响有关。目前，没有 FDA 批准的预防顺铂引起的听力损失的疗法。 HMG-CoA 还原酶抑制剂（他汀类药物）由于假定的多效性作用、减少炎症和氧化应激而受到关注。一些临床前和回顾性研究表明，同时服用他汀类药物可以减少顺铂相关的听力损失。目的： … WebThirteen percent sustained a significant hearing handicap. An interindividual variation was found, ranging from severe hearing loss after the first course to unaffected hearing after …

WebNov 21, 2024 · Cisplatin chemotherapy causes permanent hearing loss in 40–80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is … WebFeb 24, 2024 · Cisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of …

WebApr 6, 2016 · Significance statement: Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. Its use results in significant and permanent hearing loss, for which no US Food and Drug Administration-approved treatment is currently available. WebAug 31, 2016 · Ototoxicity poses a major problem to the cancer patient, as the quality of life after receiving cisplatin chemotherapy may be negatively affected due to hearing loss, resulting in social, emotional, and vocational difficulties, as effective communication is …

WebFeb 1, 2024 · Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.

WebSep 1, 2024 · Improving Ototoxicity Monitoring with Cisplatin Therapy at VA Northeast Ohio Healthcare System (VANOHS), An Interdisciplinary Team Approach. Publish date: September 1, 2024. Author(s): Lisa Arfons, MD Yasmine Ayoub, PharmD, BCPS Deborah Fox, RN, BSN, MSHS Jill Lagerstedt, MA, CCC-A, Clinical Audiologist list of supplements for type 2 diabeticsWebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs ( Spankovich et al., 2016 ). In an alternative rodent experiment, the otoprotective effect of hypothermia applied through a custom-made cooling device was evaluated in a cochlea implantation situation. immigration amnesty 1996WebTaking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10(-8), hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, immigration amnesty billWebCisplatin-induced hearing loss is mainly attributed to oxidative stress, but recent data suggest that inflammation could be the trigger event leading to inner ear cell death through endoplasmic reticulum (ER) stress, autophagy, necroptosis, and then intrinsic apoptosis. immigration amnestyWebLovastatin protects against cisplatin-induced hearing loss in mice. Cisplatin is used to treat a variety of solid tumors in both children and adults. However, cisplatin has serious … immigration amnesty 1986WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … immigration all over the worldWebMar 15, 2024 · Cisplatin can cause hearing loss in up to 60% of the treated population, leading to significant impact on QoL. Data from a population-based longitudinal study of age-related hearing impairment (N = 2,688) showed that 28% of adults age 53-97 years … list of supplements that are blood thinners